A new species of the genus Campylaspis G.O. Sars, C. grazielae and also Campylaspis sp. are described from the mesophotic coral ecosystems of St. John, US Virgin Islands, Caribbean Sea. Similarities and dissimilarities with related species are discussed and a taxonomic key is provided for the Western Atlantic species of the genus Campylaspis. With the addition of C. grazielae sp. nov. described herein, there are 17 recognized species of Campylaspis in the Western Atlantic. This is the first record of the genus Campylaspis from the US Virgin Islands.