Synalpheopsis gen. nov. is established for a remarkable new alpheid species, Synalpheopsis laureae sp. nov., presently known only from the male holotype collected at 111–162 m east of La Désirade, Guadeloupe, Lesser Antilles. Synalpheopsis gen. nov. peculiarly combines features of two genera, Alpheopsis Coutière, 1897 and Synalpheus Spence Bate, 1888; however, it is presumably closer to the former genus. The new genus is characterised by the moderately developed orbital hoods, well-developed rostrum and orbital teeth, sixth pleonite without articulated flap, tip of the third maxilliped with crown of spiniform setae, chelipeds with two strong teeth on distolateral margin and lacking snapping mechanism on finger cutting edges, and gill formula without mastigobranchs and setobranchs.